T2 Mapping in Duchenne Muscular Dystrophy: Distribution of Disease Activity and Correlation with Clinical Assessments
نویسندگان
چکیده
منابع مشابه
Left ventricular T2 distribution in Duchenne Muscular Dystrophy
BACKGROUND Although previous studies have helped define the natural history of Duchenne muscular dystrophy (DMD)-associated cardiomyopathy, the myocardial pathobiology associated with functional impairment in DMD is not yet known.The objective of this study was to assess the distribution of transverse relaxation time (T2) in the left ventricle (LV) of DMD patients, and to determine the associat...
متن کاملSerial assessment of myocardial T2 in Duchenne muscular dystrophy
Background Duchenne Muscular Dystrophy (DMD), a lethal X-linked skeletal and cardiac myopathy, affects 1/3500 males[1-2]. MRI studies have shown occult ventricular dysfunction and myocardial fibrosis in DMD patients. Previously we used the Full Width of Half Maximum (FWHM) of T2 distribution in LV to quantify the myocardial structural heterogeneity in DMD patients. In DMD subject groups, we sho...
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Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
متن کاملMyocardial T1 and T2 Mapping in Duchenne muscular dystrophy: characterization of late gadolinium Eenhancement
Background In the current era, cardiovascular disease is the leading cause of death in patients with Duchenne muscular dystrophy (DMD). Pathological studies demonstrate myocardial fibrosis that begins in the subepicardium of the left ventricular free wall. Late gadolinium enhancement (LGE) images demonstrate a similar pattern of extracellular matrix (ECM) expansion. However, based on a baseline...
متن کاملDetection of the Duplication in Exons 56-63 of Duchenne Muscular Dystrophy Patients with MLPA
Background Duchenne Muscular Dystrophy (DMD) is a deadly X-linked recessive disorder. This genetic disorder affects 1 among 3,500-5,000 males in the world. The majority of the patients are male, due to the type of inheritance. It affects most of the skeletal, the respiratory, and cardiac muscles, causing these vital organs to contract and eventually mortality.<br...
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ژورنال
عنوان ژورنال: Radiology
سال: 2010
ISSN: 0033-8419,1527-1315
DOI: 10.1148/radiol.10091547